Dangers of a damaged gut microbiome - IBD, Coeliac, IBS, MS, Asthma etc.

Summary

These studies suggest gut dysbiosis can cause inflammatory, autoimmune, metabolic, neoplastic, neurodegenerative, intestinal, extra-intestinal, and kidney diseases.

Introduction

Gut dysbiosis, an imbalance in the gut microbiota, has been linked to various long-term health conditions. This imbalance can disrupt the normal functions of the gut microbiome, leading to a cascade of health issues. Understanding the conditions associated with gut dysbiosis is crucial for developing targeted therapeutic strategies.

Key Insights

• Inflammatory and Autoimmune Diseases:

  • Gut dysbiosis is associated with inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and coeliac disease.

  • Dysbiosis can drive immune system dysregulation, contributing to autoimmune diseases.

• Metabolic Disorders:

  • Dysbiosis is linked to obesity, metabolic syndrome, and cardiovascular diseases.

  • Altered gut microbiota can lead to metabolic imbalances and the production of harmful metabolites.

• Neurodegenerative Diseases:

  • There is a strong connection between gut dysbiosis and neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis.

  • Dysbiosis can disrupt the gut-brain axis, leading to chronic neuroinflammation and neurodegeneration.

• Kidney Diseases:

  • Gut dysbiosis is implicated in the pathogenesis and progression of kidney diseases.

  • Harmful metabolites produced due to dysbiosis can exacerbate kidney conditions.

• Allergies and Asthma:

  • Dysbiosis is associated with the development of allergies and asthma, likely due to its impact on immune system regulation.

• Chronic Diseases and Aging:

  • Dysbiosis contributes to chronic diseases and unhealthy ageing, leading to systemic inflammation and increased mortality.

  • Age-related changes in the gut microbiota can exacerbate chronic health conditions.

Conclusion

Gut dysbiosis is linked to a wide range of long-term conditions, including inflammatory and autoimmune diseases, metabolic disorders, neurodegenerative diseases, kidney diseases, allergies, asthma, and chronic diseases associated with ageing. Addressing gut dysbiosis through targeted therapies could mitigate these conditions and improve overall health outcomes.

Sources:

1. M. Levy et al. "Dysbiosis and the immune system." Nature Reviews Immunology, 17 (2017): 219-232.

2. Antonella Gagliardi et al. "Rebuilding the Gut Microbiota Ecosystem." International Journal of Environmental Research and Public Health, 15 (2018).

3. M. Zeng et al. "Mechanisms of inflammation-driven bacterial dysbiosis in the gut." Mucosal Immunology, 10 (2016): 18-26.

4. L. Buttó et al. "Dysbiosis in intestinal inflammation: Cause or consequence.." International journal of medical microbiology : IJMM, 306 5 (2016): 302-309 .

5. S. Chidambaram et al. "Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle.." Pharmacology & therapeutics (2021): 107988 .

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